Neuroblastoma tyrosine kinase signaling networks involve FYN and LYN in endosomes and lipid rafts.

ABSTRACT: Protein phosphorylation plays a central role in creating a highly dynamic network of interacting proteins that reads and responds to signals from growth factors in the cellular microenvironment. Cells of the neural crest employ multiple signaling mechanisms to control migration and differentiation during development. It is known that defects in these mechanisms cause neuroblastoma, but how multiple signaling pathways interact to govern cell behavior is unknown. In a phosphoproteomic study of neuroblastoma cell lines and cell fractions, including endosomes and detergent-resistant membranes, 1622 phosphorylated proteins were detected, including more than half of the receptor tyrosine kinases in the human genome. Data were analyzed using a combination of graph theory and pattern recognition t

SUBMITTER: Palacios-Moreno J 

PROVIDER: S-EPMC4401789 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature