Gene expression changes between patent and fused cranial sutures in a nonsyndromic craniosynostosis population.

ABSTRACT:

Objective

Craniosynostosis is a premature fusion of 1 or more cranial sutures. It may occur with additional morphological abnormalities (syndromic) or in isolation. Studies suggest that dysregulation of normal cell proliferation, differentiation, and migration has a role in isolated or nonsyndromic craniosynostosis but the molecular mechanisms remain unknown. The aim of this research is to identify genes differentially expressed in prematurely fused human suture compared to patent suture in nonsyndromic craniosynostosis.

Methods

Bone fragments from synostosed and patent sutures of 7 infants with nonsyndromic craniosynostosis were collected during surgical release of fused sutures. RNA was isolated from the fragments (7 patent and 7 fused) and global gene expression profiled

SUBMITTER: Potter AB 

PROVIDER: S-EPMC4401998 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature