Comparative efficacy of switching to natalizumab in active multiple sclerosis.

ABSTRACT:

Objective

To compare treatment efficacy and persistence in patients who switched to natalizumab versus those who switched between glatiramer acetate (GA) and interferon-beta (IFNβ) after an on-treatment relapse on IFNβ or GA using propensity score matched real-world datasets.

Methods

Patients included were registered in MSBase or the TYSABRI Observational Program (TOP), had relapsed on IFNβ or GA within 12 months prior to switching to another therapy, and had initiated natalizumab or IFNβ/GA treatment ≤6 months after discontinuing prior therapy. Covariates were balanced across post switch treatment groups by propensity score matching at treatment initiation. Relapse, persistence, and disability measures were compared between matched treatment arms in the total population (n 

SUBMITTER: Spelman T 

PROVIDER: S-EPMC4402083 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature