Validating a dimensionless number for glucose homeostasis in humans.

ABSTRACT: Understanding type 2 diabetes is challenged by the diversity of patient phenotypes. Translating data across species and among individuals is a barrier for understanding the genetic loci that underpin this multifactorial disease. Dynamic scaling, based upon dimensional analysis, is a common technique in engineering used to translate data among different systems. The objective of this study was to gain insight using dimensional analysis into the relative changes in insulin production capacity vs. insulin-dependent glucose metabolism in patient groups that represent distinct stages of disease progression. A dimensionless number was derived using variables involved in the production of insulin and in the sensitivity of glucose metabolism to insulin. The resulting dynamic scaling relationship w

SUBMITTER: Klinke DJ 

PROVIDER: S-EPMC4402237 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature