Antibodies generated against Streptococci protect in a mouse model of disseminated aspergillosis.

ABSTRACT: Invasive aspergillosis (IA) resulting from infection by Aspergillus fumigatus is a leading cause of death in immunosuppressed populations. There are limited therapeutic options for this disease and currently no vaccine. There is evidence that some anti-A. fumigatus mAbs can provide protection against IA. However, vaccine development has been impeded by a paucity of immunological targets on this organism demonstrated to provide protective responses. Sialylated oligosaccharide epitopes found on a variety of pathogens, including fungi and group B streptococci (GBS), are thought to be major virulence factors of these organisms facilitating pathogen attachment to host cells and modulating complement activation and phagocytosis. Because some of these oligosaccharide structures are conserved acro

SUBMITTER: Wharton RE 

PROVIDER: S-EPMC4402265 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature