Advances in the treatment of invasive neonatal candidiasis.

ABSTRACT:

Introduction

Invasive candidiasis is responsible for ∼ 10% of nosocomial sepsis in very-low-birth-weight infants and is associated with substantial morbidity and mortality. Over the last two decades, the antifungal armamentarium against Candida spp. has increased; however, efficacy and safety studies in this population are lacking.

Areas covered

We reviewed the medical literature and extracted information on clinical and observational studies evaluating the use of antifungal agents in neonates with invasive candidiasis.

Expert opinion

Efficacy and safety data for antifungals in neonates are lacking, and the majority of studies conducted to date have concentrated on pharmacokinetic/pharmacodynamic evaluations. Unlike other anti-infective agents, efficacy data in the se

SUBMITTER: Botero-Calderon L 

PROVIDER: S-EPMC4402277 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature