Cholera-toxin suppresses carcinogenesis in a mouse model of inflammation-driven sporadic colon cancer.

ABSTRACT: Human studies and clues from animal models have provided important links between gastrointestinal (GI) tract bacteria and colon cancer. Gut microbiota antigenic stimuli play an important role in shaping the intestinal immune responses. Therefore, especially in the case of inflammation-associated colon cancer, gut bacteria antigens may affect tumorigenesis. The present study aimed to investigate the effects of the oral administration of a bacterial product with known immunomodulatory properties on inflammation-driven colorectal neoplasmatogenesis. For that, we used cholera-toxin and a well-established mouse model of colon cancer in which neoplasia is initiated by a single dose of the genotoxic agent azoxymethane (AOM) and subsequently promoted by inflammation caused by the colitogenic subst

SUBMITTER: Doulberis M 

PROVIDER: S-EPMC4402334 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature