Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

ABSTRACT:

Background

Cardiovascular diseases are among the most significant health problems in the United States. Blood pressure (BP) variability has a genetic component, and most of the genetic variance remains to be identified. One promising strategy for gene discovery is genome-wide analysis of interactions between single nucleotide polymorphisms (SNPs) and environmental factors related to cardiovascular diseases.

Methods

We investigated SNP-smoking interaction effects on BP in genome-wide data in 6,889 participants from the Framingham Heart Study. We performed the standard 1 degree of freedom (df) test of the interaction effect and the joint 2 df test of main and interaction effects. Three smoking measures were used: cigarettes per day (CPD), pack years of smoking, and smoking sta

SUBMITTER: Sung YJ 

PROVIDER: S-EPMC4402348 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature