Aldosterone, cognitive function, and cerebral hemodynamics in hypertension and antihypertensive therapy.

ABSTRACT:

Background

Animal studies suggest that the renin-angiotensin-aldosterone system is involved in neurocognitive function and the response to antihypertensive therapy. We investigated the impact of circulating aldosterone and renin activity on cognition and cerebral hemodynamics at baseline and after antihypertensive therapy for 1 year.

Methods

Participants were older adults (n = 47; mean age = 71 years) enrolled in a clinical trial. Routine antihypertensive medications were replaced with the study regimen to achieve a blood pressure <140/90 mm Hg. Executive function, memory, cerebral hemodynamics (blood flow velocity), CO2 vasoreactivity (measured using transcranial Doppler ultrasonography), plasma renin activity, and aldosterone were measured at baseline and at 6 and 12 month

SUBMITTER: Hajjar I 

PROVIDER: S-EPMC4402350 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature