Effect of prior cancer on outcomes in advanced lung cancer: implications for clinical trial eligibility and accrual.

ABSTRACT: Prior cancer is a common exclusion criterion in lung cancer trials. This practice reflects concerns that prior cancer may affect trial conduct or outcomes. However, the impact of prior cancer on survival in lung cancer is not known. We identified patients older than age 65 years with stage IV lung cancer diagnosed between 1992 and 2009 in the Surveillance, Epidemiology, and End Results-Medicare linked registry. Prior cancer was characterized by type, stage, and timing. All-cause and lung cancer-specific survival were compared between patients with and without prior cancer using propensity score-adjusted Cox regression. Overall, 102 929 patients with stage IV lung cancer were identified, of whom 14.7% had a history of prior cancer. More than two-thirds (76.0%) of prior cancers were localize

SUBMITTER: Laccetti AL 

PROVIDER: S-EPMC4402360 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature