Combining bevacizumab and chemoradiation in rectal cancer. Translational results of the AXEBeam trial.

ABSTRACT:

Background

This study characterises molecular effect of bevacizumab, and explores the relation of molecular and genetic markers with response to bevacizumab combined with chemoradiotherapy (CRT).

Methods

From a subset of 59 patients of 84 rectal cancer patients included in a phase II study combining bevacizumab with CRT, tumour and blood samples were collected before and during treatment, offering the possibility to evaluate changes induced by one dose of bevacizumab. We performed cDNA microarrays, stains for CD31/CD34 combined with α-SMA and CA-IX, as well as enzyme-linked immunosorbent assay (ELISA) for circulating angiogenic proteins. Markers were related with the pathological response of patients.

Results

One dose of bevacizumab changed the expression of 14 genes

SUBMITTER: Verstraete M 

PROVIDER: S-EPMC4402460 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature