CYP7A1 gene polymorphism located in the 5' upstream region modifies the risk of coronary artery disease.

ABSTRACT:

Background

7-Alpha cholesterol hydroxylase (CYP7A1), the first enzyme of classic conversion pathway leading from cholesterol to bile acids synthesis, is encoded by CYP7A1 gene. Its single nucleotide polymorphisms (SNPs) influence serum lipid levels and may be related to impaired lipid profile leading to coronary artery disease (CAD). The aim of the present study was to analyze the possible association between the rs7833904 CYP7A1 polymorphism and premature CAD.

Material and methods

Serum lipid levels and rs7833904 SNP were determined in 419 subjects: 200 patients with premature CAD and 219 age and sex matched controls.

Results

The A allele carrier state was associated with CAD (OR = 1.76, 95% CI; 1.14-2.71, P = 0.014). The effect was even stronger in the male subgroup

SUBMITTER: Iwanicki T 

PROVIDER: S-EPMC4402502 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature