Ontology highlight
ABSTRACT:
SUBMITTER: Kim KB
PROVIDER: S-EPMC4402520 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20150312 7
Histone H3K9 methyltransferase (HMTase) G9a-mediated transcriptional repression is a major epigenetic silencing mechanism. UHRF1 (ubiquitin-like with PHD and ring finger domains 1) binds to hemimethylated DNA and plays an essential role in the maintenance of DNA methylation. Here, we provide evidence that UHRF1 is transcriptionally downregulated by H3K9 HMTase G9a. We found that increased expression of G9a along with transcription factor YY1 specifically represses UHRF1 transcription during TPA- ...[more]