Evolutionary patterns of DNA base composition and correlation to polymorphisms in DNA repair systems.

ABSTRACT: DNA base composition is a fundamental genome feature. However, the evolutionary pattern of base composition and its potential causes have not been well understood. Here, we report findings from comparative analysis of base composition at the whole-genome level across 2210 species, the polymorphic-site level across eight population comparison sets, and the mutation-site level in 12 mutation-tracking experiments. We first demonstrate that base composition follows the individual-strand base equality rule at the genome, chromosome and polymorphic-site levels. More intriguingly, clear separation of base-composition values calculated across polymorphic sites was consistently observed between basal and derived groups, suggesting common underlying mechanisms. Individuals in the derived groups show

SUBMITTER: Li X 

PROVIDER: S-EPMC4402523 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature