Serum vaccine antibody concentrations in children exposed to perfluorinated compounds.

ABSTRACT:

Context

Perfluorinated compounds (PFCs) have emerged as important food contaminants. They cause immune suppression in a rodent model at serum concentrations similar to those occurring in the US population, but adverse health effects of PFC exposure are poorly understood.

Objective

To determine whether PFC exposure is associated with antibody response to childhood vaccinations.

Design, setting, and participants

Prospective study of a birth cohort from the National Hospital in the Faroe Islands. A total of 656 consecutive singleton births were recruited during 1997-2000, [corrected] and 587 participated in follow-up through 2008.

Main outcome measures

Serum antibody concentrations against tetanus and diphtheria toxoids at ages 5 and 7 years.

Results

Simila

SUBMITTER: Grandjean P 

PROVIDER: S-EPMC4402650 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature