Abnormalities of lipoprotein concentrations in obstructive sleep apnea are related to insulin resistance.

ABSTRACT:

Study objective

Prevalence of cardiovascular disease (CVD) is increased in patients with obstructive sleep apnea (OSA), possibly related to dyslipidemia in these individuals. Insulin resistance is also common in OSA, but its contribution to dyslipidemia of OSA is unclear. The study's aim was to define the relationships among abnormalities of lipoprotein metabolism, clinical measures of OSA, and insulin resistance.

Design

Cross-sectional study. OSA severity was defined by the apnea-hypopnea index (AHI) during polysomnography. Hypoxia measures were expressed as minimum and mean oxygen saturation, and the oxygen desaturation index. Insulin resistance was quantified by determining steady-state plasma glucose (SSPG) concentrations during the insulin suppression test. Fasting plas

SUBMITTER: Liu A 

PROVIDER: S-EPMC4402673 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature