Decreased Regional Cerebral Perfusion in Moderate-Severe Obstructive Sleep Apnoea during Wakefulness.

ABSTRACT:

Study objectives

To investigate gray matter volume and concentration and cerebral perfusion in people with untreated obstructive sleep apnea (OSA) while awake.

Design

Voxel-based morphometry to quantify gray matter concentration and volume. Arterial spin labeling perfusion imaging to quantify cerebral perfusion.

Setting

Lying supine in a 3-T magnetic resonance imaging scanner in the early afternoon.

Participants

19 people with OSA (6 females, 13 males; mean age 56.7 y, range 41-70; mean AHI 18.5, range 5.2-52.8) and 19 controls (13 females, 6 males; mean age: 50.0 y, range 41-81).

Interventions

N/A.

Measurements and results

There were no differences in regional gray matter concentration or volume between participants with OSA and controls. Neither

SUBMITTER: Innes CR 

PROVIDER: S-EPMC4402676 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature