Isolation and characterization of a native avirulent strain of Streptococcus suis serotype 2: a perspective for vaccine development.

ABSTRACT: Streptococcus suis, an emerging infectious pathogen, is the cause of two large-scale outbreaks of human streptococcal toxic shock syndrome in China, and has attracted much attention from the scientific community. The genetic basis of its pathogenesis remains enigmatic, and no effective prevention measures have been established. To better understand the virulence differentiation of S. suis and develop a promising vaccine, we isolated and sequenced a native avirulent S. suis strain (05HAS68). Animal experiments revealed that 05HAS68 is an avirulent strain and could protect piglets from the attack of virulent strains. Comparative genomics analyses demonstrated the genetic basis for the lack of virulence in 05HAS68, which is characterized by the absence of some important virulence-associated f

SUBMITTER: Yao X 

PROVIDER: S-EPMC4402706 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature