The association between the rs11549465 polymorphism in the hif-1α gene and cancer risk: a meta-analysis.

ABSTRACT:

Purpose

The associations between hypoxia-inducible factor-1 alpha (HIF-1alpha) and clinicopathological characteristics of cancers have been evaluated in various studies, with the conflicting results. The common rs11549465 (1772C/T) genetic polymorphism has been reported to be functional and may contribute to genetic susceptibility to cancers. However, the association between rs11549465 (1772C/T) and cancer risk remains inconclusive.

Methods

To better understand the role of rs11549465 (1772C/T) polymorphism in global cancer, we conducted this comprehensive meta-analysis encompassing 7807 cases and 8633 controls.

Results

Overall, the rs11549465 (1772C/T) genetic polymorphism was associated with higher cancer risk, especially exists in Asians. In the stratified analysis,

SUBMITTER: Li Y 

PROVIDER: S-EPMC4402731 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature