Association of MYOC and APOE promoter polymorphisms and primary open-angle glaucoma: a meta-analysis.

ABSTRACT:

Background

Primary open-angle glaucoma (POAG) is the most common form of glaucoma with a genetic predisposition. The relationship between polymorphisms in MYOC or APOE promoter region and POAG has been addressed in many case-control studies, but the published results were not consistent.

Methods

A meta-analysis assessing the association between five single nucleotide polymorphisms (SNPs) (in MYOC promoter: rs12035719 and rs2075648; in APOE promoter: rs405509, rs769446 and rs449647) and the risk of POAG was performed based on included studies from literature research. In fixed effect model or random effect model, the Mantel-Haenszel (M-H) pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to evaluate the genetic association. Stratification analysis was

SUBMITTER: Guo H 

PROVIDER: S-EPMC4402783 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature