Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of cervical cancer.

ABSTRACT:

Purpose

The objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer.

Methods

A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI).

Results

Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, sign

SUBMITTER: Wang L 

PROVIDER: S-EPMC4402788 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature