Polymorphisms of COL4A1 gene are associated with arterial pulse wave velocity in healthy Han Chinese and Uygur subjects.

ABSTRACT: Pulse wave velocity (PWV) is a noninvasive index of arterial stiffness and an independent predictor of cardiovascular outcomes. Type IV collagen is an important structural component of the vascular basement membrane, thus it is important for the integrity and functions of basement membrane. However, the relationship between genetic polymorphisms of COL4A1 gene and PWV in healthy Han Chinese and Uygur subjects remains unclear. We aimed to investigate the association between PWV and COL4A1 genetic polymorphisms in healthy Han Chinese and Uygur subjects. A total of 1533 subjects (909 Han, 624 Uygur) were selected from the Cardiovascular Risk Survey (CRS) study. Two SNPs (rs605143 and rs565470) were genotyped by using the polymerase chain reaction-restriction fragment length (PCR-RFLP) method.

SUBMITTER: Adi D 

PROVIDER: S-EPMC4402869 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature