Polymorphisms in UGT2B4 and susceptibility to pancreatic cancer.

ABSTRACT: As an important enzyme in the conjugation phase of drug clearance, UGT2B4 helps metabolize various endogenous and exogenous substances, and polymorphisms in the corresponding gene can influence enzyme activity. This study investigated the association between polymorphisms in UGT2B4 and the risk of developing pancreatic cancer in Han Chinese individuals. A hospital-based case-control study was conducted with 1579 healthy controls and 406 pancreatic cancer patients from China. Genomic DNA was obtained from peripheral blood lymphocytes. Time-of-flight mass spectrometry was used to genotype polymorphic loci in UGT2B4, and the association between these polymorphisms and susceptibility to pancreatic cancer was expressed as odds ratios (ORs) with 95% confidence intervals (CIs), as calculated usin

SUBMITTER: Che X 

PROVIDER: S-EPMC4402870 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature