Mitochondrial oxidative stress corrupts coronary collateral growth by activating adenosine monophosphate activated kinase-α signaling.

ABSTRACT:

Objective

Our goal was to determine the mechanism by which mitochondrial oxidative stress impairs collateral growth in the heart.

Approach and results

Rats were treated with rotenone (mitochondrial complex I inhibitor that increases reactive oxygen species production) or sham-treated with vehicle and subjected to repetitive ischemia protocol for 10 days to induce coronary collateral growth. In control rats, repetitive ischemia increased flow to the collateral-dependent zone; however, rotenone treatment prevented this increase suggesting that mitochondrial oxidative stress compromises coronary collateral growth. In addition, rotenone also attenuated mitochondrial complex I activity and led to excessive mitochondrial aggregation. To further understand the mechanistic pathway(s

SUBMITTER: Pung YF 

PROVIDER: S-EPMC4402936 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature