Identification of amino acid substitutions supporting antigenic change of influenza A(H1N1)pdm09 viruses.

ABSTRACT:

Unlabelled

The majority of currently circulating influenza A(H1N1) viruses are antigenically similar to the virus that caused the 2009 influenza pandemic. However, antigenic variants are expected to emerge as population immunity increases. Amino acid substitutions in the hemagglutinin protein can result in escape from neutralizing antibodies, affect viral fitness, and change receptor preference. In this study, we constructed mutants with substitutions in the hemagglutinin of A/Netherlands/602/09 in an attenuated backbone to explore amino acid changes that may contribute to emergence of antigenic variants in the human population. Our analysis revealed that single substitutions affecting the loop that consists of amino acid positions 151 to 159 located adjacent to the receptor bindin

SUBMITTER: Koel BF 

PROVIDER: S-EPMC4403388 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature