Local evolutionary patterns of human respiratory syncytial virus derived from whole-genome sequencing.

ABSTRACT:

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Human respiratory syncytial virus (RSV) is associated with severe childhood respiratory infections. A clear description of local RSV molecular epidemiology, evolution, and transmission requires detailed sequence data and can inform new strategies for virus control and vaccine development. We have generated 27 complete or nearly complete genomes of RSV from hospitalized children attending a rural coastal district hospital in Kilifi, Kenya, over a 10-year period using a novel full-genome deep-sequencing process. Phylogenetic analysis of the new genomes demonstrated the existence and cocirculation of multiple genotypes in both RSV A and B groups in Kilifi. Comparison of local versus global strains demonstrated that most RSV A variants observed locally in Kilifi were also se

SUBMITTER: Agoti CN 

PROVIDER: S-EPMC4403408 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature