Structural basis for host membrane remodeling induced by protein 2B of hepatitis A virus.

ABSTRACT:

Unlabelled

The complexity of viral RNA synthesis and the numerous participating factors require a mechanism to topologically coordinate and concentrate these multiple viral and cellular components, ensuring a concerted function. Similarly to all other positive-strand RNA viruses, picornaviruses induce rearrangements of host intracellular membranes to create structures that act as functional scaffolds for genome replication. The membrane-targeting proteins 2B and 2C, their precursor 2BC, and protein 3A appear to be primarily involved in membrane remodeling. Little is known about the structure of these proteins and the mechanisms by which they induce massive membrane remodeling. Here we report the crystal structure of the soluble region of hepatitis A virus (HAV) protein 2B, consisti

SUBMITTER: Vives-Adrian L 

PROVIDER: S-EPMC4403417 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature