Ontology highlight
ABSTRACT:
SUBMITTER: Oh CM
PROVIDER: S-EPMC4403443 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150413
Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis. Here we show 5-HT regulates white and brown adipose tissue function. Pharmacological inhibition of 5-HT synthesis leads to inhibition of lipogenesis in epididymal white adipose tissue (WAT), induction of browning in inguinal WAT and activation of adaptive thermogenesis in brown adipose tissue (BAT). Mice with inducible Tph1 K ...[more]