Broad-spectrum inhibitors against 3C-like proteases of feline coronaviruses and feline caliciviruses.

ABSTRACT:

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Feline infectious peritonitis and virulent, systemic calicivirus infection are caused by certain types of feline coronaviruses (FCoVs) and feline caliciviruses (FCVs), respectively, and are important infectious diseases with high fatality rates in members of the Felidae family. While FCoV and FCV belong to two distinct virus families, the Coronaviridae and the Caliciviridae, respectively, they share a dependence on viral 3C-like protease (3CLpro) for their replication. Since 3CLpro is functionally and structurally conserved among these viruses and essential for viral replication, 3CLpro is considered a potential target for the design of antiviral drugs with broad-spectrum activities against these distinct and highly important viral infections. However, small-molecule inh

SUBMITTER: Kim Y 

PROVIDER: S-EPMC4403489 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature