A computational analysis of stoichiometric constraints and trade-offs in cyanobacterial biofuel production.

ABSTRACT: Cyanobacteria are a promising biological chassis for the synthesis of renewable fuels and chemical bulk commodities. Significant efforts have been devoted to improve the yields of cyanobacterial products. However, while the introduction and heterologous expression of product-forming pathways is often feasible, the interactions and incompatibilities of product synthesis with the host metabolism are still insufficiently understood. In this work, we investigate the stoichiometric properties and trade-offs that underlie cyanobacterial product formation using a computational reconstruction of cyanobacterial metabolism. First, we evaluate the synthesis requirements of a selection of cyanobacterial products of potential biotechnological interest. Second, the large-scale metabolic reconstruction a

SUBMITTER: Knoop H 

PROVIDER: S-EPMC4403605 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature