Evolutionary Conservation of Bacterial Essential Metabolic Genes across All Bacterial Culture Media.

ABSTRACT: One of the basic postulates of molecular evolution is that functionally important genes should evolve slower than genes of lesser significance. Essential genes, whose knockout leads to a lethal phenotype are considered of high functional importance, yet whether they are truly more conserved than nonessential genes has been the topic of much debate, fuelled by a host of contradictory findings. Here we conduct the first large-scale study utilizing genome-scale metabolic modeling and spanning many bacterial species, which aims to answer this question. Using the novel Media Variation Analysis, we examine the range of conservation of essential vs. nonessential metabolic genes in a given species across all possible media. We are thus able to obtain for the first time, exact upper and lower bound

SUBMITTER: Ish-Am O 

PROVIDER: S-EPMC4403854 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature