MAESTRO--multi agent stability prediction upon point mutations.

ABSTRACT:

Background

Point mutations can have a strong impact on protein stability. A change in stability may subsequently lead to dysfunction and finally cause diseases. Moreover, protein engineering approaches aim to deliberately modify protein properties, where stability is a major constraint. In order to support basic research and protein design tasks, several computational tools for predicting the change in stability upon mutations have been developed. Comparative studies have shown the usefulness but also limitations of such programs.

Results

We aim to contribute a novel method for predicting changes in stability upon point mutation in proteins called MAESTRO. MAESTRO is structure based and distinguishes itself from similar approaches in the following points: (i) MAESTRO impleme

SUBMITTER: Laimer J 

PROVIDER: S-EPMC4403899 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature