Homozygous haplotype deficiency reveals deleterious mutations compromising reproductive and rearing success in cattle.

ABSTRACT:

Background

Cattle breeding populations are susceptible to the propagation of recessive diseases. Individual sires generate tens of thousands of progeny via artificial insemination. The frequency of deleterious alleles carried by such sires may increase considerably within few generations. Deleterious alleles manifest themselves often by missing homozygosity resulting from embryonic/fetal, perinatal or juvenile lethality of homozygotes.

Results

A scan for homozygous haplotype deficiency in 25,544 Fleckvieh cattle uncovered four haplotypes affecting reproductive and rearing success. Exploiting whole-genome resequencing data from 263 animals facilitated to pinpoint putatively causal mutations in two of these haplotypes. A mutation causing an evolutionarily unlikely substitution

SUBMITTER: Pausch H 

PROVIDER: S-EPMC4403906 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature