Prediction of brain age suggests accelerated atrophy after traumatic brain injury.

ABSTRACT:

Objective

The long-term effects of traumatic brain injury (TBI) can resemble observed in normal ageing, suggesting that TBI may accelerate the ageing process. We investigate this using a neuroimaging model that predicts brain age in healthy individuals and then apply it to TBI patients. We define individuals' differences in chronological and predicted structural "brain age," and test whether TBI produces progressive atrophy and how this relates to cognitive function.

Methods

A predictive model of normal ageing was defined using machine learning in 1,537 healthy individuals, based on magnetic resonance imaging-derived estimates of gray matter (GM) and white matter (WM). This ageing model was then applied to test 99 TBI patients and 113 healthy controls to estimate brain age.<

SUBMITTER: Cole JH 

PROVIDER: S-EPMC4403966 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature