Codon usage and codon context bias in Xanthophyllomyces dendrorhous.

ABSTRACT:

Background

Synonymous codons are used differentially in organisms from the three domains of life, a phenomenon referred to as codon usage bias. In addition, codon pair bias, particularly in the 3' codon context, has also been described in several organisms and is associated with the accuracy and rate of translation. An improved understanding of both types of bias is important for the optimization of heterologous protein expression, particularly in biotechnologically important organisms, such as the yeast Xanthophyllomyces dendrorhous, a promising bioresource for the carotenoid astaxanthin. Using genomic and transcriptomic data, the codon usage and codon context biases of X. dendrorhous open reading frames (ORFs) were analyzed to determine their expression levels, GC% and sequence l

SUBMITTER: Baeza M 

PROVIDER: S-EPMC4404019 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature