Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population.

ABSTRACT:

Introduction

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease. Currently, numerous genetic loci of SLE have been confirmed. Here we try to further explore additional genes contributing to SLE susceptibility in this study.

Methods

Forty nine single nucleotide polymorphisms (SNPs) with moderate-risk for SLE in previous study were genotyped in a large-scale replication study with a total of 3,522 cases and 8,252 controls using the Sequenom Massarray system. Association analyses were performed using logistic regression with gender or sample cohorts as a covariate through PLINK 1.07 software.

Results

This replication effort confirmed five reported SLE susceptibility loci reaching genome-wide levels of significance (P(meta) <5.00 × 10(-08)): TNFSF4 (rs

SUBMITTER: Sheng YJ 

PROVIDER: S-EPMC4404072 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature