Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock.

ABSTRACT:

Introduction

We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemorrhagic shock.

Methods

We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients.

Results

We found that there was no difference in injury severity between the aged (age ≥55, n = 533) and young (age <55, n = 1395) cohorts. However, aged patients had more comorbidities. Advanced age was associated with more severe organ failure, infectious complications, ventilator days, and intensive care unit length of stay, as well as, an increased likelihood of being discharged to skilled nursing or long-term care facilities. Addition

SUBMITTER: Vanzant EL 

PROVIDER: S-EPMC4404112 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature