High-dose dual therapy is superior to standard first-line or rescue therapy for Helicobacter pylori infection.

ABSTRACT:

Background & aims

The efficacy of treatment of Helicobacter pylori infection has decreased steadily because of increasing resistance to clarithromycin, metronidazole, and levofloxacin. Resistance to amoxicillin is generally low, and high intragastric pH increases the efficacy of amoxicillin, so we investigated whether a combination of a high-dose proton pump inhibitor and amoxicillin (dual therapy) was more effective than standard first-line or rescue therapies in eradicating H pylori.

Methods

We performed a large-scale multihospital trial to compare the efficacy of a high-dose dual therapy (HDDT) with that of standard therapies in treatment-naive (n = 450) or treatment-experienced (n = 168) patients with H pylori infection. Treatment-naive patients were randomly assigned to

SUBMITTER: Yang JC 

PROVIDER: S-EPMC4404168 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature