NAT1, NOS3, and TYMS genotypes and the risk of conotruncal cardiac defects.

ABSTRACT:

Background

Although congenital heart defects (CHDs) are a common and serious group of birth defects, relatively little is known about the causes of these conditions, and there are no established prevention strategies. There is, however, evidence suggesting that the risk of CHDs in general, and conotruncal and related defects (CTRDs) in particular, may be associated with maternal folate status and genetic variants of folate-related genes. Although several folate-related genes have been studied as they relate to CHDs and CTRDs (e.g., MTHFR), others have not been adequately assessed.

Methods

Case-parent triads were examined using log-linear analyses to assess the associations between CTRDs and both the genotype inherited by the case and the maternal genotype for the following v

SUBMITTER: Lupo PJ 

PROVIDER: S-EPMC4404296 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature