Effective treatment of depression improves post-myocardial infarction survival.

ABSTRACT:

Aim

To examine the contribution of treatment resistant depression (TRD) to mortality in depressed post-myocardial infarction (MI) patients independent of biological and social predictors.

Methods

This secondary analysis study utilizes the Enhancing Recovery in Coronary Heart Disease (ENRICHD) clinical trial data. From 1834 depressed patients in the ENRICHD study, there were 770 depressed post-MI patients who were treated for depression. In this study, TRD is defined as having a less than 50% reduction in Hamilton Depression (HAM-D) score from baseline and a HAM-D score of greater than 10 in 6 mo after depression treatment began. Cox regression analysis was used to examine the independent contributions of TRD to mortality after controlling for the biological and social predic

SUBMITTER: Banankhah SK 

PROVIDER: S-EPMC4404376 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature