Antipsychotic drugs and risks of myocardial infarction: a self-controlled case series study.

ABSTRACT:

Aim

Antipsychotics increase the risk of stroke. Their effect on myocardial infarction remains uncertain because people prescribed and not prescribed antipsychotic drugs differ in their underlying vascular risk making between-person comparisons difficult to interpret. The aim of our study was to investigate this association using the self-controlled case series design that eliminates between-person confounding effects.

Methods and results

All the patients with a first recorded myocardial infarction and prescription for an antipsychotic identified in the Clinical Practice Research Datalink linked to the Myocardial Ischaemia National Audit Project were selected for the self-controlled case series. The incidence ratio of myocardial infarction during risk periods following the in

SUBMITTER: Brauer R 

PROVIDER: S-EPMC4404491 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature