Histone modifications induced by MDV infection at early cytolytic and latency phases.

ABSTRACT:

Background

Marek's disease (MD) is a highly contagious, lymphomatous disease of chickens induced by a herpesvirus, Marek's disease virus (MDV) that is the cause of major annual losses to the poultry industry. MD pathogenesis involves multiple stages including an early cytolytic phase and latency, and transitions between these stages are governed by several host and environmental factors. The success of vaccination strategies has led to the increased virulence of MDV and selective breeding of naturally resistant chickens is seen as a viable alternative. While multiple gene expression studies have been performed in resistant and susceptible populations, little is known about the epigenetic effects of infection.

Results

In this study, we investigated temporal chromatin signatur

SUBMITTER: Mitra A 

PROVIDER: S-EPMC4404578 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature