Evaluating intra- and inter-individual variation in the human placental transcriptome.

ABSTRACT:

Background

Gene expression variation is a phenotypic trait of particular interest as it represents the initial link between genotype and other phenotypes. Analyzing how such variation apportions among and within groups allows for the evaluation of how genetic and environmental factors influence such traits. It also provides opportunities to identify genes and pathways that may have been influenced by non-neutral processes. Here we use a population genetics framework and next generation sequencing to evaluate how gene expression variation is apportioned among four human groups in a natural biological tissue, the placenta.

Results

We estimate that on average, 33.2%, 58.9%, and 7.8% of the placental transcriptome is explained by variation within individuals, among individuals,

SUBMITTER: Hughes DA 

PROVIDER: S-EPMC4404591 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature