Ageing-associated changes in the human DNA methylome: genomic locations and effects on gene expression.

ABSTRACT:

Background

Changes in DNA methylation are among the mechanisms contributing to the ageing process. We sought to identify ageing-associated DNA methylation changes at single-CpG-site resolution in blood leukocytes and to ensure that the observed changes were not due to differences in the proportions of leukocytes. The association between DNA methylation changes and gene expression levels was also investigated in the same individuals.

Results

We identified 8540 high-confidence ageing-associated CpG sites, 46% of which were hypermethylated in nonagenarians. The hypermethylation-associated genes belonged to a common category: they were predicted to be regulated by a common group of transcription factors and were enriched in a related set of GO terms and canonical pathways. Conve

SUBMITTER: Marttila S 

PROVIDER: S-EPMC4404609 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature