Time-updated systolic blood pressure and the progression of chronic kidney disease: a cohort study.

ABSTRACT:

Background

Previous reports of the longitudinal association between achieved blood pressure (BP) and end-stage renal disease (ESRD) among patients with chronic kidney disease (CKD) have not incorporated time-updated BP with appropriate covariate adjustment.

Objective

To assess the association between baseline and time-updated systolic blood pressure (SBP) with CKD progression.

Design

Observational, prospective cohort study. (ClinicalTrials.gov: NCT00304148).

Setting

7 U.S. clinical centers.

Patients

Patients in the Chronic Renal Insufficiency Cohort Study (n = 3708) followed for a median of 5.7 years (25th to 75th percentile, 4.6 to 6.7 years).

Measurements

The mean of 3 seated SBP measurements made up the visit-specific SBP. Time-updated SBP was

SUBMITTER: Anderson AH 

PROVIDER: S-EPMC4404622 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature