A common variant in RAB27A gene is associated with fractional exhaled nitric oxide levels in adults.

ABSTRACT:

Background

Exhaled nitric oxide (FeNO) is a biomarker for eosinophilic inflammation in the airways and for responsiveness to corticosteroids in asthmatics.

Objective

We sought to identify in adults the genetic determinants of fractional exhaled nitric oxide (FeNO) levels and to assess whether environmental and disease-related factors influence these associations.

Methods

We performed a genome-wide association study of FeNO through meta-analysis of two independent discovery samples of European ancestry: the outbred EGEA study (French Epidemiological study on the Genetics and Environment of Asthma, N = 610 adults) and the Hutterites (N = 601 adults), a founder population living on communal farms. Replication of main findings was assessed in adults from an isolated villa

SUBMITTER: Bouzigon E 

PROVIDER: S-EPMC4405185 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature