Increased mortality associated with digoxin in contemporary patients with atrial fibrillation: findings from the TREAT-AF study.

ABSTRACT:

Background

Despite endorsement of digoxin in clinical practice guidelines, there exist limited data on its safety in atrial fibrillation/flutter (AF).

Objectives

The goal of this study was to evaluate the association of digoxin with mortality in AF.

Methods

Using complete data of the TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF) study from the U.S. Department of Veterans Affairs (VA) healthcare system, we identified patients with newly diagnosed, nonvalvular AF seen within 90 days in an outpatient setting between VA fiscal years 2004 and 2008. We used multivariate and propensity-matched Cox proportional hazards to evaluate the association of digoxin use with death. Residual confounding was assessed by sensitivity analysis.

Results

Of

SUBMITTER: Turakhia MP 

PROVIDER: S-EPMC4405246 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature