Cognitive correlates of gray matter abnormalities in adolescent siblings of patients with childhood-onset schizophrenia.

ABSTRACT: Patients with childhood onset schizophrenia (COS) display widespread gray matter (GM) structural brain abnormalities. Healthy siblings of COS patients share some of these structural abnormalities, suggesting that GM abnormalities are endophenotypes for schizophrenia. Another possible endophenotype for schizophrenia that has been relatively unexplored is corticostriatal dysfunction. The corticostriatal system plays an important role in skill learning. Our previous studies have demonstrated corticostriatal dysfunction in COS siblings with a profound skill learning deficit and abnormal pattern of brain activation during skill learning. This study investigated whether structural abnormalities measured using volumetric brain morphometry (VBM) were present in siblings of COS patients and whether

SUBMITTER: Wagshal D 

PROVIDER: S-EPMC4405249 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature