Identification of microRNA genes in three opisthorchiids.

ABSTRACT:

Background

Opisthorchis felineus, O. viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose a serious threat to humans in some countries and cause opisthorchiasis/clonorchiasis. Chronic disease may lead to a risk of carcinogenesis in the biliary ducts. MicroRNAs (miRNAs) are small noncoding RNAs that control gene expression at post-transcriptional level and are implicated in the regulation of various cellular processes during the parasite- host interplay. However, to date, the miRNAs of opisthorchiid flukes, in particular those essential for maintaining their complex biology and parasitic mode of existence, have not been satisfactorily described.

Methodology/principal findings

Using a SOLiD deep sequencing-bioinformatic approach, we ide

SUBMITTER: Ovchinnikov VY 

PROVIDER: S-EPMC4405270 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature