Differential effects of basolateral and apical iron supply on iron transport in Caco-2 cells.

ABSTRACT: Iron homeostasis in the human body is maintained primarily through regulation of iron absorption in the duodenum. The liver peptide hepcidin plays a central role in this regulation. Additionally, expression and functional control of certain components of the cellular iron transport machinery can be influenced directly by the iron status of enterocytes. The significance of this modulation, relative to the effects of hepcidin, and the comparative effects of iron obtained directly from the diet and/or via the bloodstream are not clear. The studies described here were performed using Caco-2 cell monolayers as a model of intestinal epithelium, to compare the effects of iron supplied in physiologically relevant forms to either the apical or basolateral surfaces of the cells. Both sources of iron

SUBMITTER: Eady JJ 

PROVIDER: S-EPMC4405506 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature